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Mapping human genetic ancestry

Friday 7th September 2007 - 09:00 to 10:00
INI Seminar Room 1
The human genome is a mosaic with respect to its evolutionary history. Based on a phylogenetic analysis of 23,210 DNA sequences alignments from human, chimpanzee, gorilla, orangutan and rhesus, we present a map of human genetic ancestry. For about 23% of our genome we share no immediate genetic ancestry with our closest living relative, the chimpanzee. This encompasses genes and exons to the same extent as intergenic regions. We, conclude that about 1/3 of our genes evolved as human specific lineages before the differentiation of human, chimps and gorillas took place. This explains recurrent findings of very old human specific morphological traits in the fossils record, which predate the recent emergence of the human species about 5 million years ago. Furthermore, the sorting of such ancestral phenotypic polymorphisms in subsequent speciation events provides a parsimonious explanation why evolutionary derived characteristics are shared among species that are not each other's closest relatives.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons