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Sequence Classification using Reference Taxonomies

Date: 
Wednesday 22nd June 2011 - 11:30 to 12:30
Venue: 
INI Seminar Room 1
Abstract: 
Next generation sequencing technologies have opened up an unprecedented opportunity for microbiology by enabling the culture-independent genetic study of complex microbial communities, which were so far largely unknown. The analysis of metagenomic data is challenging, since a sample may contain a mixture of many different microbial species, whose genome has not necessarily been sequenced beforehand. In this talk, we address the problem of analyzing metagenomic data for which databases of reference sequences are already known. We discuss both composition and alignment-based methods for the classification of sequence reads, and present recent results on the assignment of ambiguous reads to microbial species at the best possible taxonomic rank.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons