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Denaturation transition of stretched DNA in the presence of DNA-binding ligands

Wednesday 5th September 2012 - 15:40 to 16:00
INI Seminar Room 1
Stretching experiments on DNA in the presence of DNA binding ligands have been shown to reveal insight into biological processes of DNA-ligand binding. We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force and DNA-binding ligands which bind to double-stranded DNA by intercalating between two adjacent base pairs. We obtain the phase diagram of DNA denaturation as a function of temperature, stretching force, and the chemical potential of the DNA-binding ligand. Force-extension relations are compared with recent DNA stretching experiments in the presence of DNA intercalating ethidium and ruthenium complexes.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons