skip to content
 

Denaturation transition of stretched DNA in the presence of DNA-binding ligands

Date: 
Wednesday 5th September 2012 - 15:40 to 16:00
Venue: 
INI Seminar Room 1
Abstract: 
Stretching experiments on DNA in the presence of DNA binding ligands have been shown to reveal insight into biological processes of DNA-ligand binding. We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force and DNA-binding ligands which bind to double-stranded DNA by intercalating between two adjacent base pairs. We obtain the phase diagram of DNA denaturation as a function of temperature, stretching force, and the chemical potential of the DNA-binding ligand. Force-extension relations are compared with recent DNA stretching experiments in the presence of DNA intercalating ethidium and ruthenium complexes.
The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons