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Cell Motility and Signalling to the Cytoskeleton

Presented by: 
Anne Ridley
Thursday 16th July 2015 - 15:15 to 16:30
INI Seminar Room 1
Cells move in response to extracellular cues in their environment. Cell motility is driven by the cytoskeleton, principally actin filaments and microtubules. Rho family GTPases are intracellular signal transducers that coordinate cell motility through their effects on the cytoskeleton and cell adhesions. Most of the 20 human Rho GTPases cycle between a GTP-bound active form and a GDP-bound inactive form, although RhoH and Rnd proteins are constitutively GTP-bound. Rho GTPases are activated in response to a wide variety of extracellular cues. Rho GTPases are regulated by and activate a complex network of proteins, including protein kinases, which lead to changes in cytoskeletal dynamics and cell contractility. I will describe results of RNAi screens we have carried out of Rho GTPase network components, including new links between Rho family members and protein kinases.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons