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Mechanisms shaping endoplasmic reticulum

Presented by: 
Michael Kozlov
Friday 17th July 2015 - 15:15 to 16:30
INI Seminar Room 1
Membranes of intracellular organelles and transport intermediates acquire shapes with large curvatures and complex morphologies, and undergo persistent remodeling by fission and fusion. We suggest a unifying mechanistic framework for understanding how specialized peripheral membrane proteins control the intracellular membrane curvature and dynamics, and address the effects of several specific proteins. Our consideration is based on two major mechanisms by which proteins shape membranes: shallow insertion into the membrane matrix of amphipathic or hydrophobic protein domains, and membrane attachment to the strongly curved and rigid faces of hydrophilic protein scaffolds. We considering the scaffolding mechanism, by model computationally the shaping of endoplasmic reticulum (ER ) membranes by oligomers of reticulon and DP1/Yop1 family proteins. We demonstrate that membrane molding by these proteins into nearly half-cylindrical shapes underlies generation of the whole plethora of complex morphologies observed to date in ER of different cells, which include ER tubules, sheets, inter-tubular three-way junctions, inter-sheet helicoidal connections and sheet fenestrations.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons