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A mechanical basis for axes alignment in early embryogenesis - cortical flow and cytoplasmic streaming

Presented by: 
Axel Voigt
Thursday 17th September 2015 - 14:15 to 15:00
INI Seminar Room 1
Co-authors: Stephan Grill (BIOTEC - TU Dresden), Peter Gross (BIOTEC - TU Dresden), Michael Nestler (TU Dresden)

Axis alignment in early embryogenesis refers to the alignment of the principal body axis with the long axis of the embryonic eggshell. This process is important for ensuring proper cell and tissue arrangement in morphogenesis. In C. elegans zygotes, the process of aligning the anteroposterior axis of cell polarity with the long axis of the embryo eggshell is referred to as posteriorization. It arises during cell polarization and appears to be driven through cortical and cytosolic flows. Here we discuss the underlying mechanical basis of posteriorization and axis convergence by combined experimental and numerical investigations. We consider the two-way interplay between actively driven surface flow in the actomyosin cortical layer and cytoplasmic streaming, and study the redistribution of the flow organizer (the male pronucleus) through cytoplasmic streaming for axis convergence. The underlying mathematical model consideres a bulk/surface coupling which is realized using a dif fuse domain/diffuse interface approach, which will be discussed in detail together with the strong interplay between local curvature, surface and bulk flow.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons