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From Networks to Function – Computational Models of Organogenesis

Presented by: 
Dagmar Iber
Monday 7th December 2015 - 16:15 to 17:00
INI Seminar Room 1
One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties and functionalities arise from the molecular regulatory networks ­and how do they evolve? Morphogenesis provides an excellent model system to study how simple molecular networks robustly control complex pattern forming processes on the macroscopic scale in spite of molecular noise, and how important functional variants can evolve from small genetic changes. Recent advances in 3D imaging technologies, computer algorithms, and computer power now allow us to develop and analyse increasingly realistic models of biological control. In my talk, I will show how data-based modelling can be used to define mechanisms for fundamental developmental processes and I will discuss the computational challenges that arise.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons